Cannabinoid Receptors in the Central Nervous System: Their Signaling and Roles in Disease

Abstract excerpt

The identification and cloning of the two major cannabinoid (CB¬1 and CB2) receptors together with the discovery of their endogenous ligands in the late 80s and early 90s, resulted in a major effort aimed at understanding the mechanisms and physiological roles of the endocannabinoid system (ECS). Due to its expression and localization in the central nervous system (CNS), the CB1 receptor together with its...

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