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Article

The structure of Sky1p reveals a novel mechanism for constitutive activity.

Nature structural biology - 1 Feb 2001

Nolen B, Yun C Y, Wong C F, McCammon J A, Fu X D, Ghosh G

Abstract excerpt

Sky1p is the only member of the SR protein kinase (SRPK) family in Saccharomyces cerevisiae. SRPKs are constitutively active kinases that display remarkable substrate specificity and have been implicated in RNA processing. Here we present the three-dimensional structure of a fully active truncated Sky1p. Analysis of the structure and structure-based functional studies reveal that the C-terminal tail, an unusual...

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Identifiers

PMID: 11175909
DOI: 10.1038/84178

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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