Article

Furin cleavage of SARS-CoV-2 Spike promotes but is not essential for infection and cell-cell fusion

2020-08-14

Abstract excerpt

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infects cells by binding to the host cell receptor Ace2 and undergoing virus-host membrane fusion. Fusion is triggered by the protease TMPRSS2, which processes the viral Spike (S) protein to reveal the fusion peptide. SARS-CoV-2 has evolved a multibasic site at the S1-S2 boundary, which is thought to be cleaved by furin in order to prime S protein for TM...

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Literature Corpus work: 6c4251bf-0198-5aa0-8a2c-e35bed449e76
DOI: 10.1101/2020.08.13.243303

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