Article

SARS-CoV-2 variants with mutations at the S1/S2 cleavage site are generated <i>in vitro</i> during propagation in TMPRSS2-deficient cells

2020-08-28

Abstract excerpt

The spike (S) protein of Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) binds to a host cell receptor which facilitates viral entry. A polybasic motif detected at the cleavage site of the S protein has been shown to broaden the cell tropism and transmissibility of the virus. Here we examine the properties of SARS-CoV-2 variants with mutations at the S protein cleavage site that undergo inefficient pr...

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Literature Corpus work: eab3957f-9715-5d99-b26f-e153870d2638
DOI: 10.1101/2020.08.28.271163

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