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Furin cleavage of SARS-CoV-2 Spike promotes but is not essential for infection and cell-cell fusion

25 Jan 2021

Abstract excerpt

Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) infects cells by binding to the host cell receptor ACE2 and undergoing virus-host membrane fusion. Fusion is triggered by the protease TMPRSS2, which processes the viral Spike (S) protein to reveal the fusion peptide. SARS-CoV-2 has evolved a multibasic site at the S1-S2 boundary, which is thought to be cleaved by furin in order to prime S protein for...

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PMID: 33493182
DOI: 10.1371/journal.ppat.1009246

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