Article

SARS-CoV-2 and SARS-CoV spike-mediated cell-cell fusion differ in the requirements for receptor expression and proteolytic activation

2020-07-25

Abstract excerpt

<h4>ABSTRACT</h4> The severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) infects cells through interaction of its spike protein (SARS2-S) with Angiotensin-converting enzyme 2 (ACE2) and activation by proteases, in particular transmembrane protease serine 2 (TMPRSS2). Viruses can also spread through fusion of infected with uninfected cells. We compared the requirements of ACE2 expression, proteol...

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Literature Corpus work: 3bed4c5c-1afb-507f-83c8-97d89de3795b
DOI: 10.1101/2020.07.25.221135

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