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Article

Different host cell proteases activate the SARS-coronavirus spike-protein for cell-cell and virus-cell fusion.

Virology - 10 May 2011

Simmons Graham, Bertram Stephanie, Glowacka Ilona, Steffen Imke, Chaipan Chawaree, Agudelo Juliet, Lu Kai, Rennekamp Andrew J, Hofmann Heike, Bates Paul, Pöhlmann Stefan

Abstract excerpt

Severe acute respiratory syndrome coronavirus (SARS-CoV) poses a considerable threat to human health. Activation of the viral spike (S)-protein by host cell proteases is essential for viral infectivity. However, the cleavage sites in SARS-S and the protease(s) activating SARS-S are incompletely defined. We found that R667 was dispensable for SARS-S-driven virus-cell fusion and for SARS-S-activation by trypsin and...

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Identifiers

PMID: 21435673
DOI: 10.1016/j.virol.2011.02.020
PMCID: PMC3086175

Genes

ACE2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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