Article

Enhancer Reprogramming in Melanoma Immune Checkpoint Therapy Resistance

2022-09-03

Abstract excerpt

<h4>ABSTRACT</h4> Immune checkpoint blockade (ICB) therapy has improved long-term survival for patients with advanced melanoma. However, there is critical need to identify potential biomarkers of response and actionable strategies to improve response rates. Through generation and analysis of 148 chromatin modification maps for 36 melanoma samples from patients treated with anti-PD- 1, we identified significant en...

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Literature Corpus work: 01858623-2388-5dc2-8cf5-7cab8c284306
DOI: 10.1101/2022.08.31.506051

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