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Modeling corticotroph deficiency with pituitary organoids supports the functional role of <i>NFKB2</i> in human pituitary differentiation

2023-08-04

Abstract excerpt

<h4>Background</h4> Deficient Anterior pituitary with common Variable Immune Deficiency (DAVID) syndrome, combining adrenocorticotropic hormone deficiency (ACTHD) and primary hypogammaglobulinemia, is caused by NFKB2 heterozygous mutations. Nuclear factor kappa B (NFKB) signaling is a key regulator of the immune system; however, the underlying mechanism of its association with endocrine symptoms remains unknown....

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Literature Corpus work
fd55a4fb-4145-5a21-a3ea-34a16565e2aa
DOI
10.1101/2023.08.03.551772
Open publication

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Modeling corticotroph deficiency with pituitary organoids supports the functional role of <i>NFKB2</i> in human pituitary differentiationDOI 10.1101/2023.08.03.551772
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