Article

Host immunological responses facilitate development of SARS-CoV-2 mutations in patients receiving monoclonal antibody treatments

2022-09-20

Abstract excerpt

The role of host immunity in emergence of evasive SARS-CoV-2 Spike mutations under therapeutic monoclonal antibody (mAb) pressure remains to be explored. Here, we show that patients treated with various anti-SARS-CoV-2 mAb regimens develop evasive Spike mutations with remarkable speed and high specificity to the targeted mAb-binding sites. Mutations develop more frequently in immunocompromised patients and strongl...

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Literature Corpus work: 6c1ded67-0e14-5ccb-8c0a-dd9327a0d68a
DOI: 10.1101/2022.09.20.22280135

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