Article
A screen for genes of heme uptake identifies the FLC family required for import of FAD into the endoplasmic reticulum.
The Journal of biological chemistry - 28 Jul 2006
Protchenko Olga, Rodriguez-Suarez Roberto, Androphy Rachel, Bussey Howard, Philpott Caroline C
Abstract excerpt
Although Candida albicans and Saccharomyces cerevisiae express very similar systems of iron uptake, these species differ in their capacity to use heme as a nutritional iron source. Whereas C. albicans efficiently takes up heme, S. cerevisiae grows poorly on media containing heme as the sole source of iron. We identified a gene from C. albicans that would enhance heme uptake when expressed in S. cerevisiae....
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