Article
Biosynthesis of Isonitrile Lipopeptides by Conserved Non-ribosomal Peptide Synthetase Gene Clusters in <i>Actinobacteria</i>
2017-03-27
Abstract excerpt
A putative lipopeptide biosynthetic gene cluster is conserved in many species of Actinobacteria , including Mycobacterium tuberculosis and M. marinum , but the specific function of the encoding proteins has been elusive. Using both in vivo heterologous reconstitution and in intro biochemical analyses, we have revealed that the five encoding biosynthetic enzymes are capable of synthesizing a new family of ison...
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Identifiers and source
- Literature Corpus work
- 49bedcdf-c68d-5b3c-89fa-39097d301d5f
- DOI
- 10.1101/121228