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Article

CRISPR/Cas9-mediated disruption of Cmpks1 reveals its role as a key regulator of carotenoid biosynthesis and metabolic adaptation in Cordyceps militaris.

International journal of biological macromolecules - 1 Aug 2026

Wang Fen, Zhang Mengfei, Chen Sijin, Fu Shaobin, Huai Meiyu, Liu Mengqian, Meng Guoliang, Dong Caihong

Abstract excerpt

Cordyceps militaris, a renowned edible mushroom, produces orange-yellow fruiting bodies (FBs), primarily due to carotenoid accumulation. However, genetic mechanisms and functional roles underlying carotenoid biosynthesis remain poorly understood. Here, we identified Cmpks1, a light-induced gene encoding a reducing type I polyketide synthase, as a key regulator of pigment biosynthesis. Transcription of Cmpks1 was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42276496
DOI: 10.1016/j.ijbiomac.2026.152987

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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