Article
In silico screening of the impact of hERG channel kinetic abnormalities on channel block and susceptibility to acquired long QT syndrome.
Journal of molecular and cellular cardiology - 1 Jul 2014
Romero Lucia, Trenor Beatriz, Yang Pei-Chi, Saiz Javier, Clancy Colleen E
Abstract excerpt
Accurate diagnosis of predisposition to long QT syndrome is crucial for reducing the risk of cardiac arrhythmias. In recent years, drug-induced provocative tests have proved useful to unmask some latent mutations linked to cardiac arrhythmias. In this study we expanded this concept by developing a prototype for a computational provocative screening test to reveal genetic predisposition to acquired long-QT...
Topics
- Action Potentials
- Anti-Arrhythmia Agents
- Astemizole
- Cisapride
- Computer Simulation
- Gene Expression
- Genetic Predisposition to Disease
- Heart Ventricles
- Humans
- Ion Channel Gating
- Kinetics
- Long QT Syndrome
- Models, Statistical