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Article

Combining pharmacokinetic and electrophysiological models for early prediction of drug-induced arrhythmogenicity

11 Oct 2023

Abstract excerpt

In silico methods are gaining attention for predicting drug-induced Torsade de Pointes (TdP) in different stages of drug development. However, many computational models tended not to account for inter-individual response variability due to demographic covariates, such as sex, or physiologic covariates, such as renal function, which may be crucial when predicting TdP. This study aims to compare the effects of...

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PMID: 37844488
DOI: 10.1016/j.cmpb.2023.107860

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