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Article

In silico screening of the impact of hERG channel kinetic abnormalities on channel block and susceptibility to acquired long QT syndrome.

Journal of molecular and cellular cardiology - 1 Oct 2015

Romero Lucia, Trenor Beatriz, Yang Pei-Chi, Saiz Javier, Clancy Colleen E

Abstract excerpt

Accurate diagnosis of predisposition to long QT syndrome is crucial for reducing the risk of cardiac arrhythmias. In recent years, drug-induced provocative tests have proved useful to unmask some latent mutations linked to cardiac arrhythmias. In this study we expanded this concept by developing a prototype for a computational provocative screening test to reveal genetic predisposition to acquired long-QT...

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Source

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Identifiers

PMID: 26859003
DOI: 10.1016/j.yjmcc.2015.08.015
PMCID: PMC4935925

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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