Article

Redefining Parkinson's Disease by Dysregulated Genetic Networks in Distinct Cell Types

2025-09-13

Abstract excerpt

Parkinson's disease (PD) is classically linked to dopaminergic neuron loss, but emerging evidence suggests broader cellular involvement. Here we show that PD risk variants converge on distinct molecular networks across specific brain cell types, enabling stratification of patients into six subgroups: dopaminergic, oligodendrocyte progenitor cells (O), excitatory (E), dopaminergic/excitatory, dopaminergic/oligodend...

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Literature Corpus work: 6be4d043-939c-5cef-aeaf-58cfca456b5b
DOI: 10.1101/2025.09.09.674964

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