Article

Hidden structural states of proteins revealed by conformer selection with AlphaFold-NMR

2025-02-19

Abstract excerpt

<title>Abstract</title> <p>We introduce AlphaFold-NMR, a novel approach to NMR structure determination that reveals previously undetected protein conformational states. Unlike conventional NMR methods which rely on NOE-derived spatial restraints, AlphaFold-NMR combines AI-driven conformational sampling with Bayesian scoring of realistic protein models against NOESY and chemical shift data. This method uncovers al...

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Literature Corpus work: a5d21753-902c-5dd3-912a-6f6f98ef58c6
DOI: 10.21203/rs.3.rs-5994356/v1

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