Article

Genetic reduction of the translational repressors FMRP and 4E-BP2 preserves memory in mouse models of Alzheimer’s disease

2024-10-12

Abstract excerpt

Alzheimer’s disease (AD) is characterized by progressive memory decline. Converging evidence indicates that hippocampal mRNA translation (protein synthesis) is defective in AD. Here, we show that genetic reduction of the translational repressors, Fragile X messenger ribonucleoprotein (FMRP) or eukaryotic initiation factor 4E (eIF4E)-binding protein 2 (4E-BP2), prevented the attenuation of hippocampal protein synth...

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Literature Corpus work: 8bfd670a-cb12-5b72-8b6a-22e5b2063a14
DOI: 10.1101/2024.10.08.617315

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