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Pathogenic tau induces an adaptive elevation in mRNA translation rate at early stages of disease

26 Jun 2024

Abstract excerpt

Alterations in the rate and accuracy of messenger RNA (mRNA) translation are associated with aging and several neurodegenerative disorders, including Alzheimer's disease and related tauopathies. We previously reported that error-containing RNA that are normally cleared via nonsense-mediated mRNA decay (NMD), a key RNA surveillance mechanism, are translated in the adult brain of a Drosophila model of tauopathy. In...

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PMID: 38932463
DOI: 10.1111/acel.14245

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