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Synovial Sarcoma Chromatin Dynamics Reveal a Continuum in SS18:SSX Reprograming

2024-05-17

Abstract excerpt

<h4>Summary</h4> Synovial sarcoma (SyS) is an aggressive soft-tissue malignancy characterized by a pathognomonic chromosomal translocation leading to the formation of the SS18::SSX fusion oncoprotein. SS18::SSX associates with mammalian BAF complexes suggesting deregulation of chromatin architecture as the oncogenic driver in this tumour type. To examine the epigenomic state of SyS we performed comprehensive mult...

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Literature Corpus work
6b930f66-46ce-516f-a535-9d18bcf39fe2
DOI
10.1101/2024.05.14.594262
Open publication

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Synovial Sarcoma Chromatin Dynamics Reveal a Continuum in SS18:SSX ReprogramingDOI 10.1101/2024.05.14.594262
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