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Molecular Profiling Defines Three Subtypes of Synovial Sarcoma

10 Sept 2024

Abstract excerpt

Synovial Sarcomas (SS) are characterized by the presence of the SS18::SSX fusion gene, which protein product induce chromatin changes through remodeling of the BAF complex. To elucidate the genomic events that drive phenotypic diversity in SS, we performed RNA and targeted DNA sequencing on 91 tumors from 55 patients. Our results were verified by proteomic analysis, public gene expression cohorts and single-cell...

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PMID: 39257029
DOI: 10.1002/advs.202404510

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