Article

SS18::SSX redistributes BAF chromatin remodelers selectively to activate and repress transcription

2024-05-17

Abstract excerpt

<h4>SUMMARY</h4> Synovial sarcoma (SyS) is driven by the expression of a chromosomal translocation-generated SS18::SSX fusion oncoprotein 1,2 . This oncoprotein fuses the SSX carboxy terminal tail that binds ubiquitylated histone H2A (H2AK119ub) 3–6 to the SS18 component of both canonical (CBAF) and non-canonical (GBAF, GLTSCR1-containing) BAF-family chromatin remodeling complexes 7–11 , wherein SS18::SSX repr...

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Literature Corpus work: d84db2d7-58dc-58b4-b250-7f90c075e867
DOI: 10.1101/2024.05.14.594253

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