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Molecular and epigenetic oncogenesis in synovial sarcoma: implications for cancer biology, diagnosis and treatment

23 Aug 2025

Abstract excerpt

The SS18::SSX oncogene is the driver of synovial sarcoma, an aggressive cancer presenting in young adults that has poor long-term outcomes. Over the past five years, significant progress has been made in understanding the molecular, genomic, and epigenetic mechanisms underlying synovial sarcoma. This review synthesizes recent advancements in synovial sarcoma, including diagnostic pathology, genomic profiling,...

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PMID: 40849585
DOI: 10.1038/s41388-025-03547-1

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