Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

pH and Proton Sensor GPR65 Determine Susceptibility to Atopic Dermatitis

16 Jun 2021

Abstract excerpt

Abstract pH sensing by GPR65 regulates various inflammatory conditions, but its role in skin remains unknown. In this study, we performed a phenome-wide association study and report that the T allele of GPR65-intronic single-nucleotide polymorphism rs8005161, which reduces GPR65 signaling, showed a significant association with atopic dermatitis, in addition to inflammatory bowel diseases and asthma, as previously...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Allergic Rhinitis and Sensitization
Share to Asthma and respiratory diseases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Dermatology and Skin Diseases

Source

Identifiers

PMID: 34135065
DOI: 10.4049/jimmunol.2001363

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

pH and Proton Sensor GPR65 Determine Susceptibility to Atopic DermatitisPMID 34135065Read ↗

The impact of the rs8005161 polymorphism on G protein-coupled receptor GPR65 (TDAG8) pH-associated activation in intestinal inflammationSemantic proximity Read ↗

The Roles of Proton-Sensing G-Protein-Coupled Receptors in Inflammation and CancerSemantic proximity Read ↗

GPR68, a proton-sensing GPCR, mediates acid-induced visceral nociceptionSemantic proximity Read ↗

Genetic Coding Variant in GPR65 Alters Lysosomal pH and Links Lysosomal Dysfunction with Colitis Risk.Semantic proximity Read ↗

C10orf99/GPR15L Regulates Proinflammatory Response of Keratinocytes and Barrier Formation of the SkinSemantic proximity Read ↗

Dietary fiber controls blood pressure and cardiovascular risk by lowering large intestinal pH and activating the proton-sensing receptor GPR65Semantic proximity Read ↗

GPR4 Deficiency Alleviates Intestinal Inflammation in a Mouse Model of Inflammatory Bowel DiseaseSemantic proximity Read ↗

GPR15L is an epithelial inflammation-derived pruritogenSemantic proximity Read ↗

Expression profiles of proton-sensing G-protein coupled receptors in common skin tumorsSemantic proximity Read ↗

Inflammatory bowel disease susceptible gene GPR35 promotes bowel inflammation in mice.Semantic proximity Read ↗

The evolution and mechanism of GPCR proton sensing.Semantic proximity Read ↗

Proton-gating of opioid receptors and isoform functionalitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.