Article

GPR35-mediated Kynurenic Acid Sensing Acts as a Defender Against Gut Microbiota Disorder in Ulcerative Colitis

2022-10-17

Abstract excerpt

<h4>Background: </h4> Ulcerative colitis (UC) is a recurrent inflammatory disease related to gut microbiota disorder. The metabolites and their sensors play an irreplaceable role in the communication of the gut microbes with their host. Our previous study revealed that G protein-coupled receptor 35 (GPR35) was a key guardian of kynurenic acid (KA) and a core element of the defense responses against gut damage. How...

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Literature Corpus work: faa19945-03ed-5bfc-b95f-5f7765b3470f
DOI: 10.21203/rs.3.rs-2162768/v1

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