Article

Investigating TNS4 in the Colorectal Tumour Microenvironment Using 3D Spheroid Models of Invasion

2020-01-03

Abstract excerpt

TNS4 (Tensin 4 or Cten) is a putative oncogene in colorectal cancer (CRC) with a role in regulating cell adhesion, motility, invasion and epithelial to mesenchymal transition (EMT). Our objective was to study TNS4 role in CRC using more realistic models of the tumour microenvironment. CRC cells expressing TdTomato protein and shTNS4/shLUC hairpin oligos were grown in 3D spheroids with and without cancer-associated...

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Literature Corpus work: 6b7b08e9-5712-5f0f-bda9-4e7b1b39c78d
DOI: 10.1101/2020.01.03.893958

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