Article
3D imaging of colorectal cancer organoids identifies responses to Tankyrase inhibitors
2019-07-18
Abstract excerpt
Aberrant activation of the Wnt signalling pathway is required for tumour initiation and survival in the majority of colorectal cancers. The development of inhibitors of Wnt signalling has been the focus of multiple drug discovery programs targeting colorectal cancer and other malignancies associated with aberrant pathway activation. However, progression of new clinical entities targeting the Wnt pathway has been s...
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Identifiers and source
- Literature Corpus work
- 1d743aa0-f679-5cc8-bdb8-4e26c33e0235
- DOI
- 10.1101/705277