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B-Raf Inhibitors Induce Epithelial Differentiation in <i>BRAF</i> -Mutant Colorectal Cancer Cells

7 Nov 2014

Abstract excerpt

BRAF mutations are associated with aggressive, less-differentiated and therapy-resistant colorectal carcinoma. However, the underlying mechanisms for these correlations remain unknown. To understand how oncogenic B-Raf contributes to carcinogenesis, in particular to aspects other than cellular proliferation and survival, we generated three isogenic human colorectal carcinoma cell line models in which we can...

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PMID: 25381152
DOI: 10.1158/0008-5472.can-13-3686

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