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Article

Tensin-4-Dependent MET Stabilization Is Essential for Survival and Proliferation in Carcinoma Cells

1 May 2014

Abstract excerpt

Inappropriate MET tyrosine kinase receptor signaling is detected in almost all types of human cancer and contributes to malignant growth and MET dependency via proliferative and antiapoptotic activities. Independently, Tensin-4 (TNS4) is emerging as a putative oncogene in many cancer types, but the mechanisms of TNS4 oncogenic activity are not well established. Here, we demonstrate that TNS4 directly interacts...

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PMID: 24814316
DOI: 10.1016/j.devcel.2014.03.024

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