Article
Twist mediates an aggressive phenotype in human colorectal cancer cells.
International journal of oncology - 1 Mar 2016
Deng Jun-Jian, Zhang Wei, Xu Xi-Ming, Zhang Fan, Tao Wei-Ping, Ye Jun-Jie, Ge Wei
Abstract excerpt
Epithelial-mesenchymal transition (EMT) is a crucial process providing cancer cells with the ability to migrate and metastasize to distant sites. Recently, EMT was shown to be associated with the cancer stem cell (CSC) phenotype and chemoresistance. Twist is a transcription factor that regulates EMT in a various cancer cells, including colorectal cancer (CRC). Our study was done to determine the role of Twist in...
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