Article

GPR17 as an Innate Sensor for Bacterial Peptidoglycan: Implications for Necrotizing Fasciitis

2026-02-27

Abstract excerpt

<title>Abstract</title> <p>Necrotizing fasciitis (NF) is a rapidly progressive, life-threatening infection of the fascial planes that disproportionately strikes otherwise healthy individuals, implying a dominant role for host genetic susceptibility. Here we present transcriptomic and structural pharmacophore evidence supporting GPR17, a G protein-coupled receptor with established responsiveness to uracil nucleoti...

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Literature Corpus work: 6b774ac6-11a3-56e7-9737-c75e56506419
DOI: 10.21203/rs.3.rs-8968070/v1

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