Article

MrgprA3 neurons selectively control myeloid-derived cytokines for IL-17 dependent cutaneous immunity.

2023-11-30

Abstract excerpt

<title>Abstract</title> <p>Skin employs interdependent cellular networks to facilitate barrier integrity and host immunity through ill-defined mechanisms. This study demonstrates that manipulation of itch-sensing neurons bearing the Mas-related G protein-coupled receptor A3 (MrgprA3) drives IL-17+ γδ T cell expansion, epidermal thickening, and resistance to the human pathogen Schistosoma mansoni through mechanism...

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Literature Corpus work: 879ebd6b-d684-5a77-8fe7-b54c5ecd9f2b
DOI: 10.21203/rs.3.rs-3644984/v1

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