Article

Merkel Cell Polyomavirus Small Tumor Antigen Activates Matrix Metallopeptidase-9 Gene Expression for Cell Migration and Invasion

2020-03-04

Abstract excerpt

<h4>ABSTRACT</h4> Merkel cell polyomavirus (MCV) small T antigen (sT) is the main oncoprotein for the development of Merkel cell carcinoma (MCC). MCC is a rare, clinically aggressive neuroendocrine tumor of the skin with a high propensity for local, regional, and distant spread. The dysregulation of matrix metalloproteinase-9 (MMP-9) has been implicated in multiple essential roles in the development of various ma...

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Literature Corpus work: 6b764350-3f23-56e4-a5ac-1d0a0e84d258
DOI: 10.1101/2020.03.02.974303

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