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The Role of the Large T Antigen in the Molecular Pathogenesis of Merkel Cell Carcinoma

27 Aug 2024

Abstract excerpt

The large T antigen (LT) of the Merkel cell polyomavirus (MCPyV) is crucial for Merkel cell carcinoma (MCC), a rare but very aggressive form of neuroendocrine skin cancer. The clonal integration of MCPyV DNA into the host genome is a signature event of this malignancy. The resulting expression of oncogenes, including the small T (sT) antigen and a truncated form of the LT (truncLT), directly contribute to...

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PMID: 39336718
DOI: 10.3390/genes15091127

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