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Merkel cell polyomavirus small T antigen is a viral transcription activator that is essential for viral genome maintenance

27 Dec 2022

Abstract excerpt

Merkel cell polyomavirus (MCV) is a small DNA tumor virus that persists in human skin and causes Merkel cell carcinoma (MCC) in immunocompromised individuals. The multi-functional protein MCV small T (sT) activates viral DNA replication by stabilizing large T (LT) and promotes cell transformation through the LT stabilization domain (LTSD). Using MCVΔsT, a mutant MCV clone that ablates sT, we investigated the role...

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PMID: 36574443
DOI: 10.1371/journal.ppat.1011039

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