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Merkel cell polyomavirus small tumor antigen contributes to immune evasion by interfering with type I interferon signaling

2024-06-29

Abstract excerpt

Merkel cell polyomavirus (MCPyV) is the causative agent of the majority of Merkel cell carcinomas (MCC). The virus has limited coding capacity, with its early viral proteins, large T (LT) and small T (sT), being multifunctional and contributing to infection and transformation. A fundamental difference in early viral gene expression between infection and MCPyV-driven tumorigenesis is the expression of a truncated L...

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Literature Corpus work
1857a587-111c-5af2-b444-f0cab5b7e7fb
DOI
10.1101/2024.06.28.601139
Open publication

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Merkel cell polyomavirus small tumor antigen contributes to immune evasion by interfering with type I interferon signalingDOI 10.1101/2024.06.28.601139
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