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The Small Tumor Antigen of Merkel Cell Polyomavirus Accomplishes Cellular Transformation by Uniquely Localizing to the Nucleus Despite the Absence of a Known Nuclear Localization Signal

2023-11-30

Abstract excerpt

<h4>Background: </h4> Merkel Cell Carcinoma (MCC) is an aggressive skin cancer that is three times deadlier than melanoma. In 2008, it was found that 80% of MCC cases are caused by the genomic integration of a novel polyomavirus, Merkel Cell Polyomavirus (MCPyV), and the expression of its small and truncated large tumor antigens (ST and LT-t, respectively). MCPyV belongs to a family of human polyomaviruses; howeve...

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Literature Corpus work: 9f9c127d-8d33-52ce-bcf2-bcd7b60fce20
DOI: 10.21203/rs.3.rs-3682153/v1

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