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Merkel cell polyomavirus small tumor antigen contributes to immune evasion by interfering with type I interferon signaling

7 Aug 2024

Abstract excerpt

Merkel cell polyomavirus (MCPyV) is the causative agent of the majority of Merkel cell carcinomas (MCC). The virus has limited coding capacity, with its early viral proteins, large T (LT) and small T (sT), being multifunctional and contributing to infection and transformation. A fundamental difference in early viral gene expression between infection and MCPyV-driven tumorigenesis is the expression of a truncated...

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PMID: 39110744
DOI: 10.1371/journal.ppat.1012426

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