Article

Nrf2 overexpression increases risk of high tumor mutation burden in acute myeloid leukemia through inhibiting MSH2

2020-09-01

Abstract excerpt

<h4>Background: </h4> Nuclear factor erythroid 2-related factor 2 (Nrf2, also called NFE2L2) has been shown to play a pivotal role in preventing cancer cells from being affected by chemotherapy. Gene mutation is a crucial reason of chemotherapy-resistance in acute myeloid leukemia (AML). However, the relationship between Nrf2 and tumor mutation burden and its mechanism in regulating chemotherapy-resistance remains...

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Literature Corpus work: 6b5ecc3c-cd1e-556a-be55-ab08addb6c94
DOI: 10.21203/rs.3.rs-66229/v1

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