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Article

The role of NRF2 in acute myeloid leukaemia (AML)

2018-01-01

Abstract excerpt

Acute Myeloid Leukaemia refers to the excess proliferation of myeloid progenitor cells. Whilst the 5-year survival rate is 40% in younger patients, this falls to 5% in patients over 65 and resistance to front-line chemotherapy agents remain a problem. We previously identified NRF2, a regulator of anti-oxidant genes, to be constitutively activated in AML and this correlated with resistance to chemotherapy. Recent s...

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Literature Corpus work
0aa498be-69d5-53a8-a3c6-f1dafd47926b
DOI
10.17638/03022789
Open publication

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The role of NRF2 in acute myeloid leukaemia (AML)DOI 10.17638/03022789
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