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Article

Nrf2 overexpression increases risk of high tumor mutation burden in acute myeloid leukemia by inhibiting MSH2.

Cell death & disease - 5 Jan 2021

Liu Ping, Ma Dan, Wang Ping, Pan Chengyun, Fang Qin, Wang Jishi

Abstract excerpt

Nuclear factor erythroid 2-related factor 2 (Nrf2, also called NFE2L2) plays an important role in cancer chemoresistance. However, little is known about the role of Nrf2 in tumor mutation burden and the effect of Nrf2 in modulating DNA mismatch repair (MMR) gene in acute myeloid leukemia (AML). Here we show that Nrf2 expression is associated with tumor mutation burden in AML. Patients with Nrf2 overexpression had...

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Identifiers

PMID: 33414469
DOI: 10.1038/s41419-020-03331-x
PMCID: PMC7790830

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