Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of NF-E2 related factor 2 (Nrf2) on chemotherapy resistance in acute myeloid leukemia (AML) and the effect of pharmacological inhibition of Nrf2.

PloS one - 1 Jan 2017

Karathedath Sreeja, Rajamani Bharathi M, Musheer Aalam Syed Mohammed, Abraham Ajay, Varatharajan Savitha, Krishnamurthy Partha, Mathews Vikram, Velayudhan Shaji Ramachandran, Balasubramanian Poonkuzhali

Abstract excerpt

Cytarabine (Ara-C) and Daunorubicin (Dnr) forms the backbone of acute myeloid leukemia (AML) therapy. Drug resistance and toxic side effects pose a major threat to treatment success and hence alternate less toxic therapies are warranted. NF-E2 related factor-2 (Nrf2), a master regulator of antioxidant response is implicated in chemoresistance in solid tumors. However, little is known about the role of Nrf2 in AML...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antioxidants
Share to Cytarabine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Daunorubicin

Share to Gene Knockdown Techniques

Share to Inhibitory Concentration 50

Share to Kelch-Like ECH-Associated Protein 1

Share to NF-E2-Related Factor 2

Share to Response Elements

Source

Open in PubMed Open full text

Identifiers

PMID: 28505160
DOI: 10.1371/journal.pone.0177227
PMCID: PMC5432104

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of NF-E2 related factor 2 (Nrf2) on chemotherapy resistance in acute myeloid leukemia (AML) and the effect of pharmacological inhibition of Nrf2.PMID 28505160Read ↗

DNMT3A R882H mutation drives daunorubicin resistance in acute myeloid leukemia via regulating NRF2/NQO1 pathway.Semantic proximity Read ↗

Nuclear factor Nrf2 promotes glycosidase OGG1 expression by activating the AKT pathway to enhance leukemia cell resistance to cytarabineSemantic proximity Read ↗

Targeting NRF2 uncovered an intrinsic susceptibility of acute myeloid leukemia cells to ferroptosisSemantic proximity Read ↗

Nrf2 overexpression increases risk of high tumor mutation burden in acute myeloid leukemia through inhibiting MSH2Semantic proximity Read ↗

Nrf2 overexpression increases risk of high tumor mutation burden in acute myeloid leukemia by inhibiting MSH2.Semantic proximity Read ↗

The role of NRF2 in acute myeloid leukaemia (AML)Semantic proximity Read ↗

Inhibition of NRF2 signaling overcomes acquired resistance to arsenic trioxide in FLT3-mutated Acute Myeloid Leukemia.Semantic proximity Read ↗

Inhibition of the Nrf2-TrxR Axis Sensitizes the Drug-Resistant Chronic Myelogenous Leukemia Cell Line K562/G01 to Imatinib TreatmentsSemantic proximity Read ↗

Molecular mechanisms and systemic targeting of NRF2 dysregulation in cancer.Semantic proximity Read ↗

NRF-mediated autophagy and UPR: Exploring new avenues to overcome cancer chemo-resistanceSemantic proximity Read ↗

Nuclear Factor Erythroid 2-Related Factor 2 in Regulating Cancer Metabolism.Semantic proximity Read ↗

Natural Nrf2 Inhibitors: A Review of Their Potential for Cancer TreatmentSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.