Article

Different mutant RUNX1 oncoproteins program alternate haematopoietic differentiation trajectories

2020-08-11

Abstract excerpt

Mutations of the hematopoietic master regulator RUNX1 cause acute myeloid leukaemia, familial platelet disorder and other haematological malignancies whose phenotypes and prognoses depend upon the class of RUNX1 mutation. The biochemical behaviour of these oncoproteins and their ability to cause unique diseases has been well studied, but the genomic basis of their differential action is unknown. To address this qu...

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Literature Corpus work: 6b5ca9a1-91b4-5993-8b86-8d548cd660ca
DOI: 10.1101/2020.08.10.244657

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