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Article

Different mutant RUNX1 oncoproteins program alternate haematopoietic differentiation trajectories.

Life science alliance - 1 Feb 2021

Kellaway Sophie G, Keane Peter, Edginton-White Benjamin, Regha Kakkad, Kennett Ella, Bonifer Constanze

Abstract excerpt

Mutations of the haematopoietic master regulator RUNX1 are associated with acute myeloid leukaemia, familial platelet disorder and other haematological malignancies whose phenotypes and prognoses depend upon the class of the RUNX1 mutation. The biochemical behaviour of these oncoproteins and their ability to cause unique diseases has been well studied, but the genomic basis of their differential action is...

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Identifiers

PMID: 33397648
DOI: 10.26508/lsa.202000864
PMCID: PMC7812315

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