Article

ArchVelo: Archetypal Velocity Modeling for Single-cell Multi-omic Trajectories

2025-09-17

Abstract excerpt

Inferring dynamic cellular processes from static single-cell measurements remains a central challenge in genomics. Here we introduce ArchVelo, a new method for modeling gene regulation and inferring cell trajectories using single-cell simultaneous chromatin accessibility (scATAC-seq) and transcriptomic (scRNA-seq) profiling. ArchVelo represents chromatin accessibility as a set of archetypes—shared regulatory progr...

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Literature Corpus work: 9f09808e-9e62-5b59-b3d3-543e38b960d9
DOI: 10.1101/2025.09.14.676182

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