Article

Genotype-phenotype mapping identifies fetal-like CD55 <sup>+</sup> immunoregulatory cancer cells as mediators of immune escape in colorectal cancer

2026-01-09

Abstract excerpt

Immune evasion is a defining feature of advanced colorectal cancer (CRC), yet the cellular mechanisms linking cancer cell states to immune suppression remain poorly understood. To systematically map tumour-immune interactions in advanced CRC, we modelled recurrent human CRC mutations using a multiplex CRISPR-based genetically engineered mouse model platform. The resulting 20 models recapitulate key stages, genetic...

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Literature Corpus work: 6cfcbc67-eb34-5863-a4ee-edebca108872
DOI: 10.64898/2026.01.09.697991

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