Article

Expanding the coverage of regulons from high-confidence prior knowledge for accurate estimation of transcription factor activities

2023-04-01

Abstract excerpt

<h4>ABSTRACT</h4> Gene regulation plays a critical role in the cellular processes that underlie human health and disease. The regulatory relationship between transcription factors (TFs), key regulators of gene expression, and their target genes, the so called TF regulons, can be coupled with computational algorithms to estimate the activity of TFs. However, to interpret these findings accurately, regulons of high...

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Literature Corpus work: 6b04c04b-f930-5012-93c3-e4c33432f5da
DOI: 10.1101/2023.03.30.534849

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