Back to search

Article

The AMD-associated genetic polymorphism CFH Y402H confers vulnerability to Hydroquinone-induced stress in iPSC-RPE cells

2024-11-06

Abstract excerpt

Age-related macular degeneration (AMD), a degenerative disease of the macula, is caused by an interplay of diverse risk factors (genetic predisposition, age and lifestyle habits). One of the main genetic risks includes the Y402H polymorphism in complement Factor H (FH), an inhibitor of complement system activation. There has been, and continues to be, much discussion around the functional consequences of this Y402...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
6af26f27-ab55-54e9-b6e4-decbe6482be2
DOI
10.1101/2024.11.06.622214
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
The AMD-associated genetic polymorphism CFH Y402H confers vulnerability to Hydroquinone-induced stress in iPSC-RPE cellsDOI 10.1101/2024.11.06.622214
The AMD-associated genetic polymorphism CFH Y402H confers vulnerability to Hydroquinone-induced stress in iPSC-RPE cellsSemantic proximity
Complement Factor H (Y402H) polymorphism for age-related macular degeneration alters retinal lipidsSemantic proximity
The Complement Factor H (Y402H) risk polymorphism for age-related macular degeneration affects metabolism and response to oxidative stress in the retinal pigment epithelium.Semantic proximity
An Induced Pluripotent Stem Cell Patient Specific Model of Complement Factor H (Y402H) Polymorphism Displays Characteristic Features of Age-Related Macular Degeneration and Indicates a Beneficial Role for UV Light ExposureSemantic proximity
Exogenous CFH Modulates Levels of Pro-Inflammatory Mediators to Prevent Oxidative Damage of Retinal Pigment Epithelial Cells with the At-Risk CFH Y402H VariantSemantic proximity
Impaired Mitochondrial Function in iPSC-Retinal Pigment Epithelium with the Complement Factor H Polymorphism for Age-Related Macular DegenerationSemantic proximity
Non-canonical roles of CFH in retinal pigment epithelial cells revealed by dysfunctional rare CFH variantsSemantic proximity
Loss of Complement Factor H impairs antioxidant capacity and energy metabolism of human RPE cellsSemantic proximity
Oxidative Stress Susceptibility, Complement Dysregulation, and Metabolic Reprogramming in CFH Y402H Patient-Derived Choriocapillaris Endothelial CellsSemantic proximity
Oxidative Stress Susceptibility, Complement Dysregulation, and Metabolic Reprogramming in <i>CFH</i> Y402H Patient-Derived Choriocapillaris Endothelial CellsSemantic proximity
FH loss in RPE cells causes retinal degeneration in a human RPE-porcine retinal explant co-culture modelSemantic proximity
CFH exerts anti-oxidant effects on retinal pigment epithelial cells independently from protecting against membrane attack complexSemantic proximity
Select a neighboring publication to make it the new centre.