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Article

The AMD-associated genetic polymorphism CFH Y402H confers vulnerability to Hydroquinone-induced stress in iPSC-RPE cells

6 Feb 2025

Abstract excerpt

Introduction: Age-related macular degeneration (AMD), a degenerative disease of the macula, is caused by an interplay of diverse risk factors (genetic predisposition, age and lifestyle habits). One of the main genetic risks includes the Y402H polymorphism in complement Factor H (FH), an inhibitor of complement system activation. There has been, and continues to be, much discussion around the functional...

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Share to Antioxidant Activity and Oxidative Stress
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PMID: 39981241
DOI: 10.3389/fimmu.2025.1527018

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The AMD-associated genetic polymorphism CFH Y402H confers vulnerability to Hydroquinone-induced stress in iPSC-RPE cellsPMID 39981241Read ↗

The AMD-associated genetic polymorphism CFH Y402H confers vulnerability to Hydroquinone-induced stress in iPSC-RPE cellsSemantic proximity Read ↗

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Oxidative Stress Susceptibility, Complement Dysregulation, and Metabolic Reprogramming in <i>CFH</i> Y402H Patient-Derived Choriocapillaris Endothelial CellsSemantic proximity Read ↗

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